Independent research company · United Kingdom
Quantum Biodynamics is an independent research company. We work on questions where the same organising principles appear at very different scales — from molecular biology to networks of intelligence — and we treat every claim as something to be tested rather than something to be defended.
Research
01
A programme on recurring organisational structure — symmetry breaking, universality, and the transitions between order and disorder — as it appears across physics, biology, cognition and mathematics. We are interested in the parts of the description that carry over, and the parts that do not.
02
Pre-registered benchmarks and evidence-preserving pipelines for genomic prediction, with an emphasis on falsification, provenance, and separating exploratory ideas from validated claims. Current work includes a preregistered splice-prediction benchmark (currently paused) and calibration work on foundation genomic models.
03
Human, animal and ecosystem health treated as a single connected system. We look for interventions and measurements that are informative across more than one of these domains at once, and for the network structure that lets a small change in one place move a lot elsewhere.
Current work
The current programme is a set of long-form essays. Each is a single tested claim carried the whole way from first principles to a falsifier. All five are in preparation and will be released when they clear internal review.
A first-principles derivation of the relationship between the flow of time as measured by a clock and the statistical state of the system that clock is embedded in.
Why models that succeed inside a well-defined system often fail at the boundary where that system meets another one — and what can be recovered when the boundary is treated as the object of study.
Every observed distribution has already been conditioned on its own recording. A careful accounting of that conditioning, with worked examples from evolutionary biology and machine learning evaluation.
A direction-blind measure built from market microstructure that separates ordinary trading from the regimes where the usual assumptions break down.
Pharmacokinetics as an inference problem: what the same dose given to two patients tells you about their internal state, and why the answer is more useful than the dose itself.
Open questions · L0
Open questions are stated before any claim is made. Nothing below is a result. Each one says what would settle it.
Q1
Pathology reads thin 2D sections of 3D tissue. Stereology shows that some quantities (length, surface, and, with paired sections, Euler characteristic) can be estimated without bias from sections, while others need full 3D reconstruction. Settled by: comparing section-based estimates with 3D ground truth across slicing directions, and asking which invariants stay stable.
Q2
A chromatin "contact" is defined by the measurement's resolution. Winding measures such as writhe describe how strands coil without ever touching. Settled by: computing both at several resolutions of the same genome data and asking which changes less.
Q3
Real trajectories rarely repeat. Asymptotic cycles and rotation numbers give a definite winding to paths that never close. Settled by: testing whether these averages can be estimated reliably from noisy biological time series, or whether noise makes them unusable.
Approach
Every substantive question is put through an explicit test: what would a reasonable observer accept as disconfirmation, and what evidence would have to appear for that observer to change their mind. Where the stakes are high, we use multiple independent models to argue the question from different starting positions, and we keep the disagreements visible rather than averaging them away.
We are a small operation by design. Work is done in the open when doing so improves the work, and kept private when doing so protects the people or systems it touches. We do not offer services, take on external mandates, or accept unsolicited pitches.
Research on this site is staged across an explicit evidential pyramid, from pre-registration through to public-facing explainer, with a status tag and last-updated date on every object. Read how to read this site →
Contact
We read everything, and reply to what we can. Please do not send unsolicited investment proposals, fundraising decks, or partnership requests — they will not receive a response.
